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N. S. Dighe ¹, S. R. Pattan ¹, S. A. Nirmal ², R. S. Kalkotwar ¹, V. M. Gaware ¹, M. B. Hole ¹

Affiliations
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni (413736), Maharashtra, IN
2 Department of Pharmacognosy, Pravara Rural College of Pharmacy, Loni (413736), Maharashtra, IN

Abstract

Tamarindus indica (Caesalpiniaceae) bark is used in the treatment of pain traditionally, present work was undertaken to prove this scientifically by using suitable animal screening models as hot plate test and acetic acid induced writing test at the dose of 50 mg/kg, i.p. Petroleum ether extract showed significant increase in reaction time as compared to other extracts. Preliminary phytochemical test showed presence of sterols and triterpenes in the extract; hence these compounds might be responsible for analgesic activity.

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R. S. Kalkotwar ¹, R. B. Saudagar ²

Affiliations
1 Department of Pharmaceutical Sciences, Bhagwant University, Ajmer, Rajashthan, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Nashik, M.S., IN

Abstract

A Novel Series of Some 2,4,5-trisubstituted imidazole derivatives were prepared with the aim to get better antibacterial activity, antifungal activity, antitubercular and anti-inflammatory activity. The structures of synthesized compounds were supported by means of IR, ¹H NMR. Title compounds were evaluated for antibacterial activity, antifungal activity, antitubercular and anti-inflammatory activities. Among the synthesized compounds some compounds found to possess all these activities. The QSAR study for anti-inflammatory activity shows good results.

Keywords

QSAR, Antibacterial, Antifungal, Anti-Inflammatory Activity.

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